We've seen an up regulation of CD27 on both CD4+ T cell and CD8+ T cell subsets in multiple tissues in the body. However, in reading I'm getting a mixed bag of what this could mean for the cells. How does CD27 expression relate to memory phenotype and antigen recall?
Generally ish, naive T cells will express CD27, upregulate upon activation but lose when they are effector. Memory cells will go onto re-express CD27.
Ahlers, Blood, 2010 has a nice graphic associated with phenotype markers and their associations. Other good reading is from J. Borst who has done a lot of work looking at the CD27/CD70 pathway and how it relates to antigen specificity etc.
Generally ish, naive T cells will express CD27, upregulate upon activation but lose when they are effector. Memory cells will go onto re-express CD27.
Ahlers, Blood, 2010 has a nice graphic associated with phenotype markers and their associations. Other good reading is from J. Borst who has done a lot of work looking at the CD27/CD70 pathway and how it relates to antigen specificity etc.
Follow up, given different tissues and the roles T cells may be playing there how might dramatically increased CD27 expression on CD4s or 8s indicate different things in say lymph node or gut mucosa?
I think you would probably need to do some functional assays to determine any meaning, and pair with CD45RA/RO, CCR7.
Hello
I agree with Jordon Dunham , This article may help you
Good Luck
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782577/
Hi @ Joshua D Croteau ,
If you're still onto that issue, I think this article might be of help:
Article Activation phenotype, rather than central- or effector-memor...
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