Actually I want to know what really is when we say in vitro colonic drug delivery.. I have seen many papers with title colonic drug delivery in vitro colonic drug delivey but in there there is simple Dissolution profile or drug release in colonic medium! Is invitro drug delivery means simple drug release check in colonic medium ??
Normally, in all these cases the main point is about the drug dissolution in the simulated GIT media. Basically, pH, ionic strength, and surfactant presence are the composition variables. Time of residence and motility simulation are the other parameters under consideration. Colonic drug release implies pH near to 8.0 at 37 °C.
Yes, testing drug release at colonic conditions such as pH, temperature etc in-vitro . Also this may involve testing the release of drug release in acidic and slightly acidic conditions (similar to stomach and small intestines) here the test should reveal no drug release in these conditions.
Dr. Sasi plzz explain your point.. I have performed drug delivery in colonic medium drug release is very low but in gastric medium there was drug release a bit higer than i colonic medium.. i used 1.2ph .1M HCL as gastric and phosphate buffer 6.8ph 0.5M.. does colonic drug delivery means no drug release at all in both mediums ???
To acheive colonic drug delivery
1. You should prove there is no or very less drug delivery in acidic conditions (gastric)
2.Acceptable/high drug release in basic conditions (Colonic)
hope this helps
your ideal drug delivery technology to a colon must show low release in gastric and ileum conditions viz, pH, release volume,ionic strength etc etc. this I believe is what Dr Sasi is trying to reiterate. the conditions of release must therefore be highest in colonic conditions for you to achieve colonic drug delivery
I think they are two collegues dr. Fleming Martínez and dr. Sasi Yarragudi completely documented answers given and with them completely agree as necessary to simulate practically the same conditions that exist in the body in order to monitor the reaction in vitro in artificial conditions of absorption of the drug with the normal parameters that colleagues have mentioned, practically the same pH, the local temperature , intestinal motility, volume, ionic strength ETSC which is not so easy!
I wish my colleagues a lot of happiness in the work and will follow gladly its results and comments on his work!