What do you think about the use of corticoids to induce diabetes in rats ?

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Marcela Aldrovani

Hello, I never work with this experimental model, but I read that there are some controversies between different authors and so the model needs to be better studied. While some studies show that the model is characterized by peripheral resistance to insulin, others show that it is characterized by a decrease in the activity of pancreatic beta cells with consequent reduction of insulin production. Glucocorticoid-induced insulin resistance is not transient. The phenotype presented by rats is suggestive of metabolic syndrome or type 2 diabetes.

Nemanja Zdravkovic

Dear Abir,

There are many models of type 2 diabetes (T2D).

I'm sending you an article that can be helpful!

http://dmm.biologists.org/content/5/5/671

Abir Radjah

Thank you a lot for your answers dear researchers.

Hanan M. Al-Youssef

mostly, to induce diabetic in rats use streptozotosine