I am a PhD student and I am trying to establish "renal artery ligation model for renal hypertension". i am facing three main problems: 1) separation of renal artery from the vein (usually i fail and it ends with venous injury and massive bleeding), 2) high mortality rate after surgery (usually 2 from 3 rats die 3-4 days after the surgery), 3) unstable blood pressure (the blood pressure increases after the surgery then falls again nearly 4 weeks after the surgery)..
any tips regarding these three issues ?
Weight gain due to anemia and other metabolic factors is the main cause of mortality in renal artery ligation model of hypertension.
Article Influence of Renal Artery Ligation on the Contralateral Kidn...
Muhammad Yousuf thank you Dr. for your answer. However, the rats die nearly 3-5 days post-surgery with no sign of infection or poor wound healing. I think that metabolic dysfunction is not responsible for the death that early.
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