There are four FTIR graphs all of which has their caption on beneath namely Acyclovir (API), Methocel-K15M (Polymer), Ethocel Standard 45P (Polymer) and Physical mixture of these three compounds. I had made the physical mixture in accordance with my formulation where the amount of pure drug was 200 mg and the cumulative amount of other polymers were around 1100 mg. I don't have in depth knowledge about FTIR. So I will be pleased if anyone explain my issue in a simpler way. Side by side I will be happy to get some link of website or article from where I can get a basic idea of interpreting FTIR graphs in a shorter period of time and use them as reference.
Thanks in advance.
In theory, if you recalculate the graph into absorbance (A instead of T) you can calculate the fourth spectrum out from the first three Amix=c1A1+c2A2+c3A3, where c is the concentration of the mix. Differences between the theoretical and experimental spectra of mixtures should show you some interactions between functional groups (like H-bonds). In practice it is very hard to do it. If you try to do it, expect to spend a lot of time with high chance of failure. Your spectra 2 and 3 are weak, it is obvious you do not control the humidity in the lab, spectrum 4 has T>100% which shows you have problems with the baseline. The best chance is to see a sharp peak slightly shifting left or right.
Thanks a lot for your reply Mr. Grigor B Bantchev. Actually my intention was to check the compatibility issue so that I can say whether polymers I used in my formulation are compatible with the drug or not. Now, is it possible to conclude regarding compatibility issue considering %T from the above attached graphs? Thanks again..
Dear sir you can conclude the bond constsnt between atoms and the shape of bonds
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