First it is important to differentiate Crohn's from cellcept/mycophenolate GI toxicity. They look very similar on colonoscopy or biopsy. If Crohn's is confirmed, treatment is usually sequential, involving antibiotics and then higher dose steroids.  Refractory cases may require anti-TNFa therapy - very effective but higher risk of infections long-term in combination with anti-rejection medications.

I agree with Leonardo`s answer. One can consider sulphasalazine before installing the anti-TNFa treatment.

I am in full agreement with Leonarso's statements. However, in my experience the immunosuppressants which are assumed by transplanted patients often make the course of inflammatory bowel diseases less aggressive. On the other hand, in the pre-anti-TNF alpha era cyclosporin, tacrolimus and mycophenolate have been used in several open studies for the treatment of refractory inflammatory bowel diseases. And even today, current guidelines do not exclude their use in some specific circumstances.

I agree also with Leonardo. High dose of cyclosporin was recommandation in these patients.

I agree with my colleagues. Stepwise approach

should include first colonoscoy and biopsy. Second is antibiotics with steroid. Most patients response if not third is 

to think abouhi high dose cyclospoin or tacrolimus. 

I should like to suggest this paper to all discussants:

J Crohns Colitis. 2013 Jun;7(5):e196. doi: 10.1016/j.crohns.2012.11.009. Epub 2012 Dec 21.

Natural history of inflammatory bowel disease patients submitted to solid organ transplantation.

Salgueiro P, Lago P, Pedroto I.

Thank you in advance for your attention, it might be the basis for a more constructive discussion.