The ecotoxicology and human health risk of nanomaterials depend on its composition, particle size, morphology and other features. What kind of materials are you looking for?
Studies concerning the behavior of nanomaterial on the environment and human health had been less explored as it should, however at the last years this topic is getting really hot.
Nanoparticles in food, vitamins could harm human health:
A research collaboration led by Michael Shuler, the Samuel B. Eckert Professor of Chemical Engineering and the James and Marsha McCormick Chair of Biomedical Engineering, studied how large doses of polystyrene nanoparticles -- a common, FDA-approved material found in substances from food additives to vitamins -- affected how well chickens absorbed iron, an essential nutrient, into their cells.
Nanoparticles belong to those food ingredients which are in Europe under the legistlation of Novel foods. As far as I know the risk is that the nanoparticles can penetrate human membranes and tissues in a way which is harmful for their function. This discussion is active among the authorities and the risk assessment is going on. The activity on DNA structure: I do not know.