Tissue-Resident Memory T Cells are memory T cells that are parked on tissues without recirculating at pathogen entry sites. They have a specific gene-expression programme. They provide a first local response against infections reencountered. But they are envolved in many autoimmune diseases.
How many types we have of this sub-population of memory T cells?
Can Trm be target in automimmune diseases? Or can they be a tool in treating diseases like cancer or virus infectious?
How can we generate them? can they be used as prophylactic tool to prevent some infectious diseases? can they be use as new vaccine?
What are you thinking dear researchers?
You will find useful information in the links below:
https://www.ncbi.nlm.nih.gov/pubmed/22449783
www.pnas.org/content/114/46/12092
www.cell.com/immunity/abstract/S1074-7613(14)00449-X
Dear Mohammed
This links may help you
Article Vaccine-generated lung tissue–resident memory T cells provid...
Article Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense...
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