Please help determine what cells are in the proximal tubules of zebrafish. They have highly condensed nuclei, but I suspect that this is not karyopiches of apoptotic cells, but mitosis of normal cells. Or were these cells attracted outside? Is there a light cytoplasm around them or is it destroyed? There are quite a lot of them in fish samples from the control group (Fig. 1), which were injected with saline into the kidney. Something similar can be found in zebrafish in the norm http://bio-atlas.psu.edu/zf/view.php?atlas=136&s=35497, but very, very rarely.
I had significant differences in the number of such cells in fish of the control and experimental (Fig. 2-5) groups. Can a large number of these cells indicate inflammation or increased regeneration?
The distal tubule (DT) is a portion of kidney nephron between the Loop of Henle and the collecting duct system. This segment is composed of a tight epithelium with little water permeability. It reabsorbs ~5% of the NaCl filtered from the initial urine. In addition, it is partially responsible for the regulation of potassium and calcium filtrate levels, as well as its pH.
https://books.google.co.kr/books?id=0qvTBwAAQBAJ&pg=PA156&lpg=PA156&dq=why+distal+tubules+in+kidney+increasing+with+saline+injection&source=bl&ots=M2-rBhwvK7&sig=ACfU3U2yE5nE68tK-u72hbHND_E9HYL0Pg&hl=en&sa=X&ved=2ahUKEwjghITznZTqAhXHyIsBHR8-B2EQ6AEwA3oECAoQAQ#v=onepage&q=why%20distal%20tubules%20in%20kidney%20increasing%20with%20saline%20injection&f=false
Saline infusion did not modify TFpH in the PT or DT but increased NH+4 secretion by the DT in direct proportion to tubular fluid flow.
I would say that they are likely to be plasma cells - associated with inflammation
I think they are small lymphocytes, part of immune response against any antigen.
I think these are lymphocytes that are crossed out from the epithelium.
Thank you all very much for your answer to the question! These are probably really squeezed lymphocytes. What does this migration mean? I mean, why do they migrate into the lumen of the tubule? To attack protein or deposits in the lumen of the tubule? Or is it a non-specific reaction?
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