Himalee De Silva Current recommendations by the ACR for treatment of knee OA primarily involves pain relief such as NSAIDs and intra-articular steroid injections (although injections are controversial with some studies suggesting they cause cartilage loss). For obese patients exercise and weight loss is strongly recommended. End stage treatment is joint replacement surgery. To date there are no disease modifying drugs available for OA patients. See this article for more information: Article 2019 American College of Rheumatology/Arthritis Foundation G...