What are the subtypes of genome instability and the genome instability caused by the misrepair of DNA double-strand break in proliferating and nonproliferating cells,respectively?
Please be more precise about what subtypes you mean under which condition besides proliferating and resting cells.
In fact,I do not know exactly subtypes of genome instability,which are not mentioned by the general articles in this fileld.Or,can you tell me the well-established indicators of
genome instability caused by misrepair of etoposide-induced DSBs,expecially in the resting cells?Thanks.
If there is misrepair (? is this a term?) of an etoposide-induced DSB, the one and only phenotype that will come about is cell death. DSBs are toxic and must be repaired. if there is no cell death, then genome instability from a dsb repair can come from NHEJ (the error prone) pathway or MMEJ (also an error prone) pathway. There are also the variants of HR, that can cause genome instability, such as BIR (break-induced replication) or SSDA. If you can elaborate on your question than I may be able to help you understand that better.
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