Himanshu Tiwari

CRISPR-Cas9 presents both exciting scientific advancements and complex ethical and policy considerations. Scientifically, it offers unprecedented precision in gene editing, enabling the creation of disease models and potentially leading to new therapies. Ethically, concerns arise regarding safety, unintended consequences, and the potential for misuse, particularly in germline editing which can affect future generations. Policy implications include the need for robust oversight, international collaboration, and equitable access to these technologies.

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Scientific, Ethical, and Policy Implications of CRISPR-Cas9:

• Scientific Implications: Enables precise genome editing for disease resistance, crop improvement and gene therapy. Raises concerns about off-target effects and long-term impacts on ecosystems and human health.
• Ethical Implications: Germline editing poses moral questions about altering future generations. Risk of inequality if access to gene editing is limited to wealthy populations. Concerns over “designer babies” and potential misuse for non-therapeutic enhancements.
• Policy Implications: Urgent need for clear, globally harmonized regulations on gene editing. Debate over patent rights and accessibility of CRISPR technology. Policies must balance innovation with safety, transparency and public trust.