What are the practical methods used to loading the drug on the hydrogels?How?
Hydrogels can be loaded with drugs in two different ways. In the first approach, the drug can be mixed with the precursor polymer solution and gelation occurs with the drug within the matrix, while in the second approach the hydrogel can be allowed to swell in a drug solution until equilibrium swelling is reached. Afterwards, it is necessary to calculate the drug loading capacity of the hydrogel before start the drug release.
Usually, water-soluble biologically active substances are used for external use drugs by just mixing the active substances with hydrogel or adding them during formation of the hydrogel.
Hydrogels can be loaded with drugs in two different ways. In the first approach, the drug can be mixed with the precursor polymer solution and gelation occurs with the drug within the matrix, while in the second approach the hydrogel can be allowed to swell in a drug solution until equilibrium swelling is reached. Afterwards, it is necessary to calculate the drug loading capacity of the hydrogel before start the drug release.
graft copolymerization of some natural polymer with spacee then substtituted by drug produced ester or amide attachment can get controlled drug release
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