Per- and polyfluoroalkyl substances (PFASs)are a ubiquitous group of environmental chemicals that cause numerous detrimental impacts on the environment and human health. According to performed studies, these metabolically inert chemicals enter the body of humans and animals and transfer into target tissues such as liver, kidney, bone, skin, etc. with the help of protein carriers in the bloodstream. From a dermatological point of view, what toxic consequences are most likely to occur in response to the dermal bioaccumulation of environmental contaminants such as PFASs? What are the differences between possible toxic effects caused by internal dermal exposure (dermal bioaccumulation) to a chemical and external dermal exposure (dermal absorption) to the same chemical?
Thanks in advance.
Internal dermal exposure from your query appears to be chronic toxin accumulation of different toxicant posing as health risk. Case examples are emerging chemicals and heavy metals. They follow the processes of bio-accumulation, through bio-concentration and bio-accumulation leading to undue dermal irritations and severe ailments. External dermal exposures on the other hand could refer to the conditions where the skin is exposed to harsh U-V radiations without protecting its delicate nature with the resultant non-melanoma skin cancer.
Thank you Charles!
However, I think you did not conceive the question correctly. Actually, I posed two questions. Firstly, I need to know what possible toxic reactions may happen if a persistent chemical accumulates in the skin? Secondly, I wonder if possible consequences caused by the accumulation of a chemical in the skin are similar to those of the same chemical through dermal absorption.
many skin changes starting from pigmentations end with cancer
because these substances effect cell and make different reaction
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