We encountered in the camel clinic during gynecological examination of infertile females some cases with vaginal growth. By routine histological examination, vaginal adenocarcinoma and squamous cell carcimoma were diagnosed. I would like to know the predisposing factors for these cases? Are the mating behavior (frictional for 10-15 min, the penis is fibroelastic type=hard) and the chronic vaginal inflammation contributing factors? What about the condition in women or in the other animals?
Interesting question. Could the traditional bedu (and somali) treatment against camel sterility: cutting with an unsterilized razor blade any small protruding area found in the vagina play a predisposing role?
Thank you Ahmed. Did the affected camels ever delivered or were heifers? Sometime heifers have anatomical malformation like vaginal septum, double cervixes that are again crudely and traumatically addressed by traditional veterinary healers. If the affected camel ever calved was their previous delivery normal or had they been subjected to traumatic methodology like fetotomy ?
Can only speak to vaginal carcinoma in humans.
http://www.cancer.org/cancer/vaginalcancer/detailedguide/vaginal-cancer-risk-factors
Art
interesting indeed, for in humans the high risk genital hpv is responsible and these are few about 8 subtypes and I am not sure if the subtypes found in humans are the same in those camels. One would send the specimens for hpv typing.
About half of vaginal cancers in humans is associated with human papillomavirus (HPV) detection, in contrast to cervix cancer which is essentially all associated with HPV. Papillomaviruses have been detected in camels. It is possible that these cancers are related to a papillomavirus infection.
My lab has an interest in animal papillomaviruses and would be willing to test samples from these cancers. The most efficient method would be to extract DNA and send us the DNA. If interested contact me directly at [email protected].
Vaginal cancer has a very low prevalence (the less prevalent gynecologic cáncer). It seems quite different in camels.
Primary vaginal cancer is extremely rare, if we exclude vaginal adenocarcinomas related to the defunct DES exposed females in the fifties. Most of the times, vaginal cancer is an extension and an invasion of the vagina, by a primary cervical cancer, subjected to the epidemiological stimulation of HPV exposure.
Bernard Lambert MD FRCSC FACOG.
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