Globally ischemic heart disease is one of the leading cause of morbidity and mortality.
Regarding risk factors what are the most effective measures which may be opted for prevention of higher incidence due coronary heart disease.
According to various trials, statin and PCSK9 inhibitor are the two most effective drugs in prevention of IHD.
The single most important step is to get the patient to stop smoking cigarettes. Cigarette smoking can wipe out all of the gains you receive from using statins such as rosuvastatin and/or the PCSK-9 inhibitors. The trick is to get to the LDL-c goal that will stabilize/regress and subclinical (or, heaven forbid), clinical atherothrombotic plaque. Treating hypertension is a must, as is treating diabetes--but the real bang for the buck lies with cigarettes and lipids.
Most effective measure to prevent Ischaemic heart disease is Life style modification , regular interval lipid profile test, regular exercise , good control of BP and Blood sugar
Thank you Prof.Shailendra KUMAR Singh,William Feeman and Alok Kumar Bharti
Dr Bharti, I must disagree most strongly with you--unless you mean in low risk groups only. That would NOT include cigarette smokers. The single most important therapeutic measure for the prevention of atherothrombotic disease (ATD) is the cessation of cigarette smoking, which of course would be a lifestyle change. What is necessary for primary prevention of ATD is the optimization of lipids and blood pressure, and it is hard to do that with simple life style changes. Statins are almost always required to achieve lipid goals and anti-hypertensive agents for hypertension. Most younger ATD patients do not have diabetes and those that do almost always have lipid and/or blood pressure abnormalities.
I also agree with Dr Feeman's view that cigarette smoking along with stress are the most important risk factors for CVD in younger people.
Dear Dr Bharti,
Your call, but my comments are based on over 50 years of experience in the field and I guarantee you that my comments are correct.
W.E.Feeman,Jr,MD
Only and only effective way to prevent IHD is Life style modification
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