I am planning a secondary analysis study and am interested in large trials (more than 500 participants randomised) that would have recruited a typical Alzheimer's disease or dementia sample in a pragmatic setting.
The intervention isn't important, but a range of clinical and patient or carer reported outcomes would be useful.
Those with data made available to researchers would be of particular interest.
Edit for more explanation:
With thanks to those who have answered already, my original question above was not very clear.
I am not looking for a specific intervention, I am interested more in understanding the trajectories of patient and carer reported outcomes in people with Alzheimer's disease. Cohort studies are unlikely to be much help because of the large gap between assessments (and generally high attrition rates among people with dementia), and so secondary analysis of large pragmatic trials is likely to be my best option.
Hence I am looking for large trials, conducted ideally in the last ten years, with PROs assessed frequently and with data that could be made available to researchers.
I have looked at the Alzforum and other lists of trials, but there are thousands of trials reported and I thought someone might know something that would save me days of searching and trying to negotiate access to data.
Thanks again.
Hi George,
I recommend you to look here:
http://www.alzforum.org/therapeutics
This database provides a catalog of the therapeutics currently or previously tested as treatment for AD.
Regards
Monika
Just looking at clinical trials in AD in general is by far too broad I would suggest. Is there anything particular you are looking at? at any certain type of medication?
CATIE is the largest one I knew. I added the link as follow:
http://clinicaltrials.gov/ct2/show/NCT00015548