Hi, Manar, KIM KÖSTNER et al have published a very nice article on the relevance of various VDR gene polymorphisms for cancer in the journal Anticancer Research.
The VDR gene contains several polymorphisms, including three single nucleotide polymorphisms (SNPs) near the 3′ un-translated region (3′ UTR) (Taq1, Bsm1, and Apa1), identified by their restriction endonuclease sites. Although not functional these SNPs are strongly linked with a poly (A) microsatellite repeat in the 3′ UTR, which could influence VDR mRNA stability (Vasilopoulos et al., 2013).
Genetic variation at 4p12, 11q12 and 11p15 loci identifies individuals who have substantially raised risk of vitamin D insufficiency (Wang et al., 2010).
Please find the attachment files
The polymorphism related to vitamin D protein may affect serum levels of vitamin D and as mentioned by Mai Albaik and Mr. Victor, you can get more information.
Regards
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