Bechet's disorder is an auto-immune health problem. Your comments would highly be appreciated. Thank you.
Behçet's disease was initially described a triad of symptoms including oral aphthous ulcers, genital ulcers
and uveitis. It was subsequently found to be a multisystem disease characterized by other manifestations
involving the articular, cutaneous, neurological, vascular, gastrointestinal and pulmonary systems.
Generally, in patients with mild mucocutaneous and/or arthritic symptoms, local steroid and oral colchicine are the
drugs of choice. In case of moderate to severe mucocutaneous lesions, vascular, neurological and GI symptoms, systemic steroid or other immunosuppressants should be considered. Azathioprine plus steroid are the core drug treatments for uveitis. For patients with refractory eye involvement, cyclosporin A is the drug of choice.
So far, infliximab is the drug most studied fo relapsing uveitis. infliximab was able to reduce the frequency of uveitis relapse, improved visual acuity also, reduced muco-cutaneous lesions and spared the use of other immunosuppressants. Use of infliximab in neuro-Behçet was documented only in case reports. however. infliximab seems to have a role in patients who failed to response to other immunosuppressive agents.
there is limited data to support rituximab adlimumab use in BD currently.
Other novel treatments reported to reduce the number of oral ulcers include probiotic yogurts containing the bacteria
Bifidobacterium lactis, topical tacrolimus, sublingual tablets of interferon-α, zinc sulphate mouth wash and nigellar sativa oil.
Limited promising experience was obtained with off label Tocilizumab in patients who failed to response to other immunosuppressive agents including Infliximab.
My wife has suffered of an auto-immune uveitis for more than 25 years now, at first Bechet disease was mentioned as a possibility but finally ruled out, as she did not show the other typical symptoms. A precise diagnostics has never been achieved, it('s apparently is a very rare case. At first she was treated with ciclosporin, but the "secondary" effects were rather bad. Presently she receives immunoglobulins several times a year - this is an experimental treatment, which is probably mentioned in immunology conferences. It seems to be working, it has made it possible to lower significantly the corticoid doses, which also have secondary adverse effects in the long run.
Did you ask about HLA- B27?.If it´s positive this condition should be related whith spondiloarthropaties instead of articular sintoms and aTNF could be elective treatment.
I have a 52 ys old male patient dealing with "idiopatic" autoimmune uveitis (Behcet and sieronegative spondiloarthopathies have been ruled out) and we have managed to keep it under control for more than 6 years up to now with infusions of infliximab (it works perfectly for Behcet and spondiloarthropathies as well)
We have about 6000 patients of Behcet's disease in Rheumatology research center. In our experience in patients anterior uveitis only tropical drugs( corticodteroids) and oral colchicine is the drug of choice. but in mild to moderate posterior uveitis we perscrib Methotrexate and prednisolone and in more sever pan uveitis with retinal vasculitis and macular edema, we use pulse cyclophosphamide monthly with mod to high dose steroid. in our experience biologic treatments have good results in post. uveitis, but in severe cases we had not good results.
Is there something in autoimmune disease (especially Rheumatoid arthritis) that can act as the PAMP to participate in the RIG-1 pathway?
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Infectious Diseases
- Immunization
- Vaccination
- Vaccines