Are there any published papers on the comparison between the effect of metformin and oral cotraceptive pills on polycystic overian syndrome?
Hi Ahmed
Metformine (M) treatment alone or in combination with OCP is associated with weight loss and improved body composition compared with OCP, whereas free testosterone levels decreased during M+OCP or OCP. Combined treatment with M+OCP is an alternative to treatment with OCP alone to avoid weight gain in PCOS. Please see the following paper:
1. Glintborg D, Altinok ML, Mumm H, Hermann AP, Ravn P, Andersen M. Body composition is improved during 12 months' treatment with metformin alone or
combined with oral contraceptives compared with treatment with oral
contraceptives in polycystic ovary syndrome. J Clin Endocrinol Metab. 2014;99:2584-91.
2. Cinar N, Harmanci A, Bayraktar M, Yildiz BO. Ethinyl estradiol-drospirenone vs
ethinyl estradiol-drospirenone plus metformin in the treatment of lean women with
polycystic ovary syndrome. Clin Endocrinol (Oxf). 2013;78:379-84.
Best regards,
Faustino
Hello Ahmed, hope this will be of help,
A randomized, placebo-controlled, double-blind control study in adolescents with PCOS showed that metformin significantly increased the likelihood of menses 2.5-fold, lowered total testosterone concentrations by 22 percent, and improved high-density lipoprotein cholesterol levels by 15 percent, although it did not significantly affect fasting measures of insulin sensitivity or body weight(1)
When metformin and OCPs are used in combination, the positive effects of metformin on high-density lipoprotein levels are counterbalanced by the negative effects of OCPs on these lipids(2)
You can also refer to UPTODATE for an extensive overview of TREATMENT OF PCOS
1. Bridger T, MacDonald S, Baltzer F, Rodd C. Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome. Arch Pediatr Adolesc Med 2006; 160:241.
2. Bredella MA, McManus S, Misra M. Impact of metformin monotherapy versus metformin with oestrogen-progesterone on lipids in adolescent girls with polycystic ovarian syndrome. Clin Endocrinol (Oxf) 2013; 79:199.
http://www.uptodate.com/contents/treatment-of-polycystic-ovary-syndrome-in-adolescents?source=search_result&search=polycystic+ovarian+syndrome&selectedTitle=8~150#H20
http://www.uptodate.com/contents/treatment-of-polycystic-ovary-syndrome-in-adults?source=search_result&search=polycystic+ovarian+syndrome&selectedTitle=3~150
Metformin and oral contraceptive pills (OCPs) are commonly used treatments for PCOS. Metformin improves insulin sensitivity and regulates menstrual cycles, while OCPs regulate cycles and reduce androgen levels. Studies show metformin’s effectiveness in improving metabolic parameters and menstrual irregularities (PMID: 21302921), and OCPs’ efficacy in managing PCOS symptoms like hirsutism and acne (PMID: 18375013). These treatments can be used alone or together, depending on individual symptoms and fertility goals.
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