What are the distinct roles of interleukin 4 and 13 to the host and parasite during schistosomiasis?

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Grant Gallagher

hmmm I'm not sure of the answer, but if I were researching the question I'd also consider the role of IL-33 and ST2, in order to gain insight to the role of the new nuocyte populations in the gut.

Good Luck!

Iris Janet Gonzalez-Leal

IL-4 and IL-13 are hallmarks for a Th2-type immune response, which is induced during schistosomiasis.

Check out these publications:

"Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology"

http://www.sciencedirect.com/science/article/pii/S1471492213002158

"Interleukin-4 (IL-4) and IL-13 Suppress Excessive Neutrophil Infiltration and Hepatocyte Damage during Acute Murine Schistosomiasis Japonica"

http://iai.asm.org/content/80/1/159.full

"Schistosomiasis Reveals the Role of IL-13 in Chronic Inflammatory Disease"

http://www.landesbioscience.com/pdf/04Brombacher_Wynn.pdf

Chantal Agbemabiese

Thanks Iris Janet. Very useful publications.