Could somebody with expertise in methods of drug administration point me in the right direction? I'm working with a new polymer which can be customized to degrade in different pH environments along the GI tract, and I was wondering about the challenges faced/applications of current technologies. I can't find much information on pH-sensitive hard shell capsule materials other than hypromellose. Is this a beneficial property? Can it be used for site-specific drug targeting etc?
Any feedback is much appreciated!
I'm not an expert at this point on galenic formulations. However there are a large amount of compounds that are either sensible to pH, or sensible to a certain interval of pH. And that means that yes, that certainly can modulate sipe-specific drug delivery. When it comes to modifies alliteration of a drug we can refer 4 main types. Repeated, prolonged, sunstained and retarded. Is my perspective it is defininaly a avantatge. Perhaps you should research more along the line of pharmaceutical technology and not so much as on the polymer itself. Search for colonic alliteration devices for instance. If I can help you more please feel free to send a message!
Dear Eaton,
I suggest looking at this from the point of view of pathologies of diseases of the gastrointestinal tract.
For example pancreatitis is treated with very large doses on enzymes because the enzymes are sensitive to pH of the stomach and easily digested. Controlling drug release relative to local pH conditions may allow for discrete drug administration as the capsule travels through the gut and this may allow significantly smaller doses. Of course this example assumes absorption of enzymes would occur after the stomach etc...
Best, Patrick.
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