When we perform dissolution studies of niosomal formulations how much volume of dissolution medium and how much quantity of niosomal formulation be added into dialysis bag, what consideration should be taken into account for this??
The volume of dissolution medium and amount of formulation that is to be taken is based on the solubility of the drug in the medium. Check the dissolution of the drug in the medium. The drug release from the niosomes at particular time interval should be quantifiable by the method used.
I completely agree with Mr. Vikram Shenoy. Additionally, if the model drug is already in the market (commercial product), you might want to consider the strength of that dosage as well. This will make your product (formulations) more relevant to the commercial products. Then, consider the solubility of the drug in a particular dissolution medium. In my personal experience, one does not need to use a 900mL dissolution vessel for doing such dissolution study. You can simply conduct it in a glass vial, less than 50 mL size. I hope this will work for you.
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