What are the best transgenic wistar rat models for Alzheimer's disease?

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How Download/Extract citations of 1 given year ALL my publications in Google Scholar?

If you google this you find a lot of smart guys explaining you how to download 1 year of citations of 1 single paper of yours (or anyone else). I mean 1 year of ALL my papers. or ... ALL years or...

01 March 2021 1,121 9 View

What keeps journals from switching to a "publish, then review" model of publishing?

A few scientific journals have started implementing a "publish, then review" model of publishing. It is explained well in this article: Implementing a "publish, then review" model of...

13 January 2021 5,449 2 View

Is there any project for a new translation of Freud's 1895 Entwurf einer Psychologie into English?

I'm far from being a Freud expert, but, my feeling is the 1950 translation by J. Strachey is in many ways outdated, when not misleading (starting form the very title of the essay, the awful choice...

10 December 2020 7,005 2 View

What is the main difference of diluting HCL in methanol as opposed to water?

I am hoping to determine the mass per unit area (as per DIN 50938) of a black oxide coating. I use water to achieve the required 1mol/l hydrochloric acidic solution, but a fellow lab had used...

06 December 2020 4,806 1 View

Linear Mixed Models for repeated measures - how can I restructure my data set when some variables are only collected at baseline?

Hello, I plan to perform a linear mixed model analysis to look at change in cognitive function over 5 follow up waves. I am interested in looking at how this change is influenced by dietary and...

27 November 2020 5,087 3 View

Mendeley profiles will be removed in December. What will be of the reader counts from Mendeley as early impact predictors?

Elsevier announced that Mendeley profiles will be discontinued from December. There is a study (Mendeley readership counts: An investigation of temporal and... ) that confirms the value of...

01 November 2020 4,832 4 View

Assessing MCMC convergence by matrix-parameter?

Hello everyone, I need to assess whether a MCMC chain (implemented in BayPass 2.2) has reached convergence and, as far as I know, in order to check it, I must look at the posterior distribution of...

27 October 2020 6,170 3 View

Searching for reliable antibodies for the adrenergic receptors alpha1D and alpha2A for western blotting?

Dear all, I am looking for reliable antibodies for the adrenergic receptors alpha1D and alpha2A, to use in Western Blotting on human skeletal muscle tissue. Anyone with experience with good...

25 October 2020 9,421 2 View

What is the best way to start and develop a scientific collaboration?

What advice would you give to a young researcher who has to develop his/her ability to produce collaborative scientific work?

22 October 2020 5,934 8 View

Temporal noise analysis CMOS APS?

I was reading the paper "Analysis of Temporal Noise in CMOS Photodiode Active Pixel Sensor" but I am a bit puzzled about noise calculation during integration. In particular, can someone explain...

15 October 2020 9,597 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

What analysis to choose with a large neste dataset and clearly skewed or kurtotic distributions?

Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...

02 March 2021 6,865 1 View

Is there a method of determining feed digestibility without the need to re-pellet the feed?

I am aiming to determine the ADC values of a commercial fish feed, but I do not have a steam pelleter or extruder available to me. Ideally, the pellets could be coated with some inert marker....

28 February 2021 7,967 3 View

Can Ethovision store the generated data and video recordings directly to NAS system?

The size of data generated by Ethovision is huge. Having NAS system for data storage seems to be a good option, I am wondering whether Ethovision can directly store the data to the NAS system...

27 February 2021 6,350 2 View

How to plot the probability paper of Gumbel distribution using R programing?

In R-studio, there are many commands of Gumbel package. Arguments are also different. I`m asking about the alpha parameter of the Copula which must be greater than 1. If this is the one used to...

25 February 2021 5,229 3 View

What are the pros and cons for mice versus rats?

Hi Everyone, I am designing a pilot study using rodents to assess the effects of simulated space environments (radiation + altered gravity) on microbiome and immune system. I have limited...

24 February 2021 1,825 3 View

How to handle studies which report perfect effect sizes in a meta-analysis using Pearson's r?

I'm in the process of updating a meta-analysis and in one of the new studies, effect sizes are reported as Tau-U. Two of the effect sizes are reported as Tau-U = 1.00. I am using Andy Field's...

24 February 2021 2,265 3 View

Are there methods for automatically mapping floodplains, fans and terraces?

I want to map these river geoforms with as little subjectivity as possible. I have a high resolution DEM generated by drone data.

22 February 2021 7,800 3 View

What should be the duration of exposure to simulated space environments with Rodents?

Hi, I am currently working on a pilot study to get some data related to the impact of long duration spaceflight to the microbiome and the immune system. I plan to use rats and simulate...

22 February 2021 592 1 View

How we can measure Kemp % in wool without using of benzene?

Would you please let me to know about the methods for measurement of medullation and Kemp % on animal? My problem is that the wool sampling and sending to laboratory is not possible. So I would...

21 February 2021 7,260 4 View

Ali A R Aldallal

The rat as an animal model of Alzheimer’s disease

Eirikur Benedikz,a,†* Ewa Kloskowska,a,† and Bengt Winbladb

Abstract

As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer’s disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that of mice. In recent years, the rat has been making a comeback as an Alzheimer’s disease model and the appearance of increasing numbers of transgenic rats will be a welcome and valuable complement to the existing mouse models. This review summarizes the contributions and current status of the rat as an animal model of Alzheimer’s disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496102/

Andrea Cabrera-Pastor

Thank you for your suggestion.