ANOVA or ANCOVA?

I made an interventional study, with 2 groups control and intervention group, with measurement at baseline, after 3 months and 6 months, what is the best statistical test to evaluate if the...

02 March 2020 7,334 4 View

2 way ANOVA is it useful? is there any alternative?

Can I know how to perform comparison between 2 groups (intervention vs control) for a parameter which obtained at 0, 3 and 6 months (3 readings) and the data is abnormally distributed?

02 March 2020 5,859 3 View

Sample size calculation in randomized clinical trials??

09 October 2019 5,342 4 View

Retention rate in clinical trials?

Can a researcher get higher than the desired sample size in one arm of the study? Example if the sample size is 60 patients (30 in each arm) and one assumes 30% loss to follow up with a total of...

09 October 2019 8,177 6 View

What is the required sample size for randomized clinical trial among diabetic patients?

If previous studies showed a reduction of 0.71% in Hba1c (SD = 0.55) in inetrvention group and 0.25% (SD=0.47) in control group what will be the required sample size for this study to achieve 0.05...

06 July 2018 786 15 View

Is it reasonable to do a research on a new drug when its expected side effect is serious?

I just read news on medscape and found the following status: The research team is hoping to start trials of a plasminogen activator inhibitor 1 (PAI-1), TM5614, to examine its effects on insulin...

10 November 2017 8,468 5 View

What is the best reliability test?

Is there a reliability test other than cronbach alpha if answers to questionnaire questions with yes or no ?

09 October 2017 1,649 5 View

How to validate a questionnaire?

If someone structured a new questionnaire in arabic and did a pilot study on arabic people, but to publish the article an english version of the questionnaire is needed, then is there a need to do...

08 September 2017 8,518 7 View

How to calculate sample size?

07 August 2017 2,067 6 View

What will be the expected sample size for rare disease with 4/100000 prevalence ?

Is there any formula or calculator for measuring sample size in rare disease? especially if the researcher work in a medical center for this rare disease with nearly half of country cases

03 April 2017 4,123 18 View

Is there any test to determine the cardiovascular risk of patients with obesity? from the perspective of obesity?

We found tests to determine cardiovascular risk taking into account lipid profile, blood pressure, age, history of diabetes, other laboratories. But when weight is involved, there is a paradox. I...

02 March 2021 6,036 1 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

No title

01 March 2021 3,905 5 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How to highlight novelty in your research paper?

I have come up with a method and had written a paper on it. Paper got rejected by a journal stating that there is no theoretical novelty. I am kind of confused on why the novelty that I am able to...

28 February 2021 2,393 8 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View