Solid carriers, for example, magnetite can not carry all drugs into the body. Attaching to their surface presents great difficulties. Solid carriers are poorly eliminated from the body. Soft matter (micelles, vesicles) are formed by intermolecular bonds. You can put any drag in them. They easily disintegrate in the body with the release of the drug. Soft substances are easily removed from the body.

Solid carriers, for example, magnetite can not carry all drugs into the body. Attaching to their surface presents great difficulties. Solid carriers are poorly eliminated from the body. Soft matter (micelles, vesicles) are formed by intermolecular bonds. You can put any drag in them. They easily disintegrate in the body with the release of the drug. Soft substances are easily removed from the body.

Prof Yuri Mirgorod , thanks for making me clear re the concept of different types of carriers.

The amphiphiles nano carriers have organic parts in their structure and this helps the nano particle to act better in drug delivery systems. Another benefit of this carriers is the form of attaching drug to this organic structures as Yuri Mirgorod said. therefore, release of drug could be more controllable and reliable.

Amphiphilic block copolymers can self assemble in to core-shell type of nano or microparticles. For example PLGA-PEG copolymer. The hydrophobic moiety can act as core which can load any hydrophobic drug molecules, while the hydrophilic PEG can induce high colloidal stability (avoid aggregation).

By adjusting the hydrophobic and hydrophilic ratio in the copolymer, the solubility of block-copolymers can be controlled.

Apart from the specif science aspect, I think the main advantage of any self-assembled system is its capacity of suitable behavior according external stimuli, such as pH, salinity and temperature. This a important point when a real application is considered.

Do we need to consider the hydrophobicity and hydrophilicity of the drugs if use soft matter such micelles/vesicles?

Yes, If the drug molecule is hydrophobic, any neutral micelles could load the drug molecule with higher loading efficacy.

If the drug molecule is hydrophilic, the drug loading efficiency will be lesser.

In such case, depending on the functional group of drug molecule, cationic or anionic micelles should be fabricated to effectively load the hydrophilic drug molecule..