Hi,

Targeted therapy can be achieved efficiently via drug carrier systems employing passive or active targeting mechanisms (Mozafari, 2005, 2006). The use

of site-specific triggers that can cause drug release specifically in the target tissue is one way of improving drug bioavailability at the tumor site. Another method of increasing drug bioavailability is to obtain a higher level of liposome accumulation by active targeting. In addition, the combination of active targeting with active triggering can result in an enhanced, more specific drug

release at the tumor target site (Andresen et al., 2005). .... (for more details see the attached manuscript: Mozafari et al. 2009).

Moreover:

One of the challenges in nanotherapy is to reduce or completely

eliminate side-effects. If bioactive agents act solely on their chosen

target to produce the desired effect without causing unwanted effects

on other systems, their usefulness will be enhanced significantly

[177]. One of the most important aspects of nanomedicine

and nanotherapy is the targeting of therapeutic agents to the desired

organs and tissues using special nanocarrier systems. Because of

their unique properties, nanosystems enhance the performance of

medicines by improving their solubility and bioavailability, increasing

their stability and establishing high concentrations of bioactives

in target cells and cellular compartments in order to gain therapeutic

efficiency [17]. ...... (described more in the attached article: Maherani et al. 2011)

generally nanoparticles tend to accumulate in cancer tissue due to passive targeting resulted from loose and deformed endothelial layer of vessel directed to cancerous tissue

however to provide more specific targeting , ligand based active approach by attachment of moiety or ligand fits into target cell receptor or polymeric coating with polymers releasing the drug into the cancerous tissue.

generally nanoparticles tend to accumulate in cancer tissue due to passive targeting resulted from loose and deformed endothelial layer of vessel directed to cancerous tissue

however to provide more specific targeting , ligand based active approach by attachment of moiety or ligand fits into target cell receptor or polymeric coating with polymers releasing the drug into the cancerous tissue.

Dear Researcher,

You can use below articles to exactly understand effective site-specific targeting drug delivery systems:

Article Targeting delivery of Oxaliplatin with smart PEG-modified PA...

Article Imaging, biodistribution and in vitro study of smart 99m Tc-...