Hi all, I am looking for the metabolizing enzymes present in the above human cell lines. I could get some information about HEPG2. But nothing about HEK293 and BEAS2B. It would be great if anyone can help in this regard.
Thanks in advance
Dear Michael,
HepG2 cells have CYP1A2, CYP2C9, CYP2D6, CYP2E1, CYP3A, CYP2A13, epoxide hydrolase, EPHX1, lactate dehydrogenase, malondialdeyde and antioxidant enzymes:
https://www.ncbi.nlm.nih.gov/pubmed/15204697
https://www.ncbi.nlm.nih.gov/pubmed/20686333
http://molpharm.aspetjournals.org/content/71/3/807.full
HEK 293 cell lines have lactate dehydrogenase, malondialdeyde, CYP2A13 epoxide hydrolase, EPHX1 , and antioxidant enzymes:
https://www.ncbi.nlm.nih.gov/pubmed/20686333
http://molpharm.aspetjournals.org/content/71/3/807.full
BEAS-2B cells have CYP2A13 and epoxide hydrolase, EPHX1
http://molpharm.aspetjournals.org/content/71/3/807.full
http://www.tandfonline.com/doi/full/10.3109/03602532.2011.629832
For more information on EPHX1, please see attached file.
Hoping this will be helpful,
Rafik
Dear Professor Rafik,
Thanks a lot for your immediate and kind response. I will download these papers.
I really appreciate your help.
Thanks again
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