When performing a systematic review with meta-analysis on HR-QoL, I think it is better to pool comparative studies using the same HR-QoL instrument rather than a combination of studies with different instruments which may be confusing.
Example: a meta-analysis should not combine comparative studies using Bladder Cancer Index and others using FACT VCI. The measurement tool should be unique.
Hi Amad,
I absolutely agree with your statement. It would not be meaningful to pool estimates from different tools of measurement, even if they measure the same parameter. For such cases, best solution would be to stratify the meta-analysis based on the specific tool, and report the results distinctly for each tool included.
Regards,
Hi Imad, I think what matters is the psychometric properties of the tools used in the studies, and the specificity of the tool to the related diseases - you can also look at the domains addressed in each tool and then appraise your findings accordingly, but limiting your review to one particular instrument might not give you comprehensive results.
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