I'm working with a triple quad (TSQ Quantum Acces Max, Thermo fisher). when I use it in full scan mode, I observed a great difference in sensitivity and accuracy between Q1 and Q3. Is that normal? In data dependent method we have two mass events: the first is a full scan, the second one is a multi reaction monitoring (MRM) involving Q1 (as mass filter), Q2 (as collision cell) and Q3 as mass analyzer. The first event could be performed both using Q1 and Q3, but what is the most correct configuration setting?

Thanks in advance.