toxicological experiment required male albino rats (200 g body weight) minimum 8 rats in every group

Hi Mostafa,

Castor Beans contain ricin, which is one of the deadliest organic compounds known.

Article Ricin Toxicity: Clinical and Molecular Aspects

However Castor Oil does not contain ricin.

https://www.drugbank.ca/drugs/DB11113

re: toxicity of castor oil;

" Toxicity studies with castor oil were performed by incorporating the material at concentrations as high as 10% in diets given to F344/N rats and B6C3F1 mice of both sexes for 13 weeks. Genetic toxicity studies also were performed and were negative for mutation induction in Salmonella typhimurium, for induction of sister chromatid exchanges or chromosomal aberrations in Chinese hamster ovary cells, and for induction of micronuclei in the peripheral blood erythrocytes of mice evaluated at the end of the 13-week studies.

Exposure to castor oil at dietary concentrations as high as 10% in 13-week studies did not affect survival or body weight gains of rats or mice (10 per sex and dose). There were no biologically significant effects noted in hematologic analyses in rats.

Mild increases in total bile acids and in serum alkaline phosphatase were noted at various times during the studies in rats receiving the higher dietary concentrations of castor oil. Liver weights were increased in male rats receiving the 10% dietary concentration and in male and female mice receiving diets containing 5% or 10% castor oil. However, there were no histopathologic lesions associated with these liver changes, nor were there any compound-related morphologic changes in any organ in rats or mice.

No significant changes were noted in a screening for male reproductive endpoints, including sperm count and motility, and no changes were observed in the length of estrous cycles of rats or mice given diets containing castor oil.

Thus, no significant adverse effects of castor oil administration were noted in these studies."

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox012.pdf?utm_source=direct&utm_medium=prod&utm_campaign=ntpgolinks&utm_term=tox012

Castor oil contains ricin, one of the most toxic substances found in nature.

But consumption of castor oil itself isn’t dangerous. The toxin enzyme concentration is minimal, so using it regularly poses no threat. Even so, an overdose of castor oil could lead to digestive problems such as colic, diarrhea, and nausea

As per Ayurveda mix Castor oil with Gomutra for Sciatica pain. Sciatica with Vata Kapha predominance Mix pippali churna in Castor oil. In Lumbago pain Castor oil mix with Dasamoola kadha or Shunthi Kadha is beneficial. Always use castor seed, boil in Milk. Also, it can be used to mix with Guda. The toxicity will never be there.