I have found very few examples of successful gene delivery to the small intestine in the literature. Is anyone here working on such a project? I believe it has a huge potential for correcting diseases.
Interesting topic,
Have a look at this manuscript:
Awasthi, R., & Kulkarni, G. T. (2016). Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand?. Drug delivery, 23(2), 378-394.
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Authors say:
"... Developing a gastroretentive-controlled release drug delivery formulation is very challenging, as continuous entry of the medium in the dosage form leads to alter the density of the system ..." ... "... a controlled release dosage form offers limited advantages for drugs that have an absorption window in the upper small intestine (Siegel & Rathbone, 2012). ..." ... "... Adhesion of the dosage forms to the mucosal membrane of the stomach is an attractive approach to increase the retention of dosage form in the stomach or upper small intestine (Ponchel & Irache, 1998). These formulations utilize bioadhesive materials, namely, polyacrylic acids (Carbopol 974P and 971P), Chitosan, cholestyramine, sodium alginate, hydroxypropyl methylcellulose (HPMC), sucralfate, tragacanth, dextrin, polyethylene glycol (PEG), gliadin etc., which enables the device to adhere to the gastric mucosal wall ...".
delivery target the G Itract orajjy has potationally simple and safe doseing of gen based and for preventation and treatment diseases engreeing of novel lives bactrial systems is hopfulle
I found a company, I think called enGene, that is developing oral formulations for delivery of genes to the intestines.
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