Dear Colleagues! How correct and appropriate is it to carry out a forensic toxicological examination of drugs and psychotropic substances in biological objects (in blood, urine, hair) and a chemical examination in different materials on one lC-MS device?
IF THE CHEMICAL ANALYSIS IS DONE USING HIGH CONCENTRATIONS OF DRUG, AND THE TOX SAMPLES ARE LOW CONCENTRATIONS, THERE IS A POTENTIAL OF CROSS-CONTAMINATION. This is one of the main reasons for not using the same column. Especially if the solvent mixes are different. You could use try using the same instrument with a different column.
LC-MS can be considered as a good and effective option here, provided the analysis and the methodology got special attention. In some case the availability of instrumentation influence a lot in the analysis procedure. Attaching a link as a reference to checkout the work. https://academic.oup.com/jat/article/41/6/559/3978799
In a nutshell- there is no such issue you will face while performing.
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