We sequenced the exons of some healthy persons, and we know that some of them run the risk of developing cancers. Is it feasible to develop preventive cancer vaccines? The vaccines would secure them from developing lung cancer, liver cancer, etc. Thanks.
Till date only vaccine against cancer is Vaccine against Cervical cancer.
This vaccine is a breakthrough of the 21st century!!
There are experimental vaccines, still in the research stage of development, against cancers that are characterized by certain mutations. For example in adult low grade glioma, mutation to isocitrate dehydrogenase 1 (IDH1) is a recurrent mutation. A paper reporting a vaccine method to inhibit tumor growth has been reported:
https://www.ncbi.nlm.nih.gov/pubmed/25043048
The field of developing vaccines against different types of cancer is promising but is starting and restricted to the cancer related to some infectious diseases
A traditional vaccine against all cancers is very unlikely. There are some strategies that try to stimulate antigen presentation and prevent inflammatory inhibitors but still, cancer is too variable and at the begining too similar to normal cells.
This is a very promising way of going on, but for the moment we are at the beginning of the road
A very interesting question. It would be feasible to start experimental work to develop preventive cancer vaccines.
As Emeritus Prof. Rodrigo states, the initial areas to begin with are probably cancers related to infectious agents.
this just out in Nature magazine a couple weeks ago. For melanoma:
https://www.ncbi.nlm.nih.gov/pubmed/?term=An+immunogenic+personal+neoantigen+vaccine+for+patients+with+melanoma
https://www.ncbi.nlm.nih.gov/pubmed/?term=Personalized+RNA+mutanome+vaccines+mobilize+poly-specific+therapeutic+immunity+against+cancer
Genome Wide Analysis Studies may be a promising way for cancer from chronic infectious diseases.
Why no?. It is a very interesting approach to a difficult problem, indeed
For vaccines against infectious agents causing cancer- preventive vaccines are eminently feasible.
For other cancers, our understanding of the pathway of chronic inflammation, dysplasia and cancer, may also help to develop vaccines that affect this mechanism.
But some of the gene modification technologies may overtake the development of vaccines in other cancers.
Cancer vaccines are a form of immunotherapy that can help educate the immune system about what cancer cells “look like” so that it can recognize and eliminate them .
A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities.
Preventive Cancer Vaccines Viral infections are responsible for the development of several cancers and preventive vaccines play an important role in reducing risk. For instance, cervical cancer and head and neck cancer can be caused by human papilloma virus, or HPV, whereas liver cancer can be caused by hepatitis B virus or HBV. Several vaccines have been developed that can prevent HBV and HPV infection and, as a result, protect against the formation of HBV- and HPV-related cancers. Four of these preventive cancer vaccines have been approved by the U.S. Food and Drug Administration (FDA). https://www.researchgate.net/publication 271660069_Prophylactic_cancer_vaccine_from_concept_to_reality
I hope that in the near future several vaccines against several canecas would be available
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