We are preparing a systematic review of the effectiveness of pro, pre- and synbiotics in patients with systemic sclerosis. We aim to evaluate and summarise available evidence on the efficacy and safety of probiotic, prebiotic and synbiotic intake in scleroderma. Does anyone know RCTs on this topic?
When we talk about systemic sclerosis, we must consider the relationship of this disease to immune and genetic mechanisms, as well as the link of this disease to the abnormal generation of extracellular collagen that develops by species of Gram-positive bacteria, including Staphylococcus, Streptococcus, Enterococcus, and Bacillus that express surface proteins. that binds to collagen
Thus, it is likely that when the patient increases the consumption of probiotics, prebiotics or synbiotics (which is preferable) that lead to strengthen the immune system and thus block one of the causes of the disease, the consumption of synbiotic products will also reduce unwanted bacteria (The above-mentioned) that promote the accumulation of abnormal collagen and this is another way that can done to suppress disease. It is known that collagen is formed as a result of a number of vital processes that take place inside the body, during which amino acids resulting from the digestion of protein-rich foods are combined. So, to ensure more effective treatment of the disease with probiotics and prebiotics supplements, it is suggested to stay away from eating protein-rich foods to reduce generation of collagen generally during the treatment period.
It is also possible to make mouthwash and masks for the skin by probiotics and their supporting materials in order to control the microbial flora in the body parts and thus reduce inflammation resulting from the disease. It is known that abnormal and even cancerous cells are suppressed by the activity of probiotics and their supporting materials (prebiotic). So if there is any collaborative relationship between malignant cells that divide abnormal inside the body and systemic sclerosis, we cut off one of the supplies that nourishes it.
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