The combination index (CI) is often used to determine whether or not a two-drug combination demonstrates synergy, where the combined effect is greater than the sum of the separate single effects. CI < 1 indicates synergism, CI = 1 indicates additivity, and CI > 1 indicates sub-additivity or antagonism. Is there a statistical method for calculating the 95% confidence interval around the CI? Can the CI with a 95% confidence interval be determined in Stata, SAS, or R software?
Hi David
Maybe those sources will be helpful:
Confidence Intervals of Interaction Index for Assessing Multiple Drug Interaction
Article Confidence Intervals of Interaction Index for Assessing Mult...
Multiple drug effect analysis with confidence interval
Article Multiple drug effect analysis with confidence interval
Confidence Intervals of Interaction Index for Assessing Multiple Drug Interaction
Article Confidence Intervals of Interaction Index for Assessing Mult...
Free software:
http://www.combosyn.com/
And discussion topic:
https://www.researchgate.net/post/How-to-calculate-Combination-Index-CI-for-drug-drug-interaction
Best regards
Tomasz
I read befor, about a specific model, called (Dose additivy model), help to predict dose combinations. I think it will be more accurate for measuring synergy dose combinations.
can we calculate 95% Confidence interval of 3 replicate, need quick answer and ref,,,,,,,,,,,plz
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