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Questions related from David Zurakowski
Research studies including randomized controlled trials often have a time-to-event outcome as the primary outcome of interest, although competing events can precede the event of interest and thus...
20 October 2022 4,616 2 View
The combination index (CI) is often used to determine whether or not a two-drug combination demonstrates synergy, where the combined effect is greater than the sum of the separate single effects....
03 March 2021 6,356 4 View
In medical and biological research we are often interested in making predictions or in building a model to predict a continuous outcome based on a continuous predictor type variable or possible...
14 November 2017 4,105 4 View
It is my understanding that Tregs can influence development of autoimmunity through complex signaling pathways. Since they are often at high levels in progression of breast, ovarian and pancreatic...
12 October 2017 5,866 3 View
Almost always in clinical research the log-rank test (Mantel-Haenszel test) is employed to compare the equality of two survival curves. Is there a good way to decide whether other tests may be...
18 May 2016 6,687 3 View
When estimating EC50 for a single drug, does one need all of the raw data at each drug concentration or simply the average response at each concentration? How does one decide what model or...
17 March 2016 5,533 8 View
Patients have several pain scores before and after medication treatment. Would like to apply a longitudinal or time series model to compare slopes before and after and evaluate the medication...
02 June 2015 5,553 9 View