for drug delivery purpose, what is a suitable method to synthesize polymer nanoparticles starting from an organic monomer?
Dear Yaseen Kareem, there are in general two strategies : In situ polymerization drug-encapsulation and post-polymerization drug-encapsulation. Conjugation is may also obey the aforementionned strategies, in addition, sometimes the drug may be used as initiator so that it will be located as a chain-end-group. Nanoparticles formation is induced by the self assembly mechanisms. My Regards
Dear Yaseen Kareem, please dont take this badly, but your question is extremely general and therefore hard to answer otherwise than with a very general answer.
The field of drug delivery is broad and many organic-based systems were developed over the years. Consequently, there is no general method of polymer nanoparticle synthesis. What drugs are you considering? What is the area of application? Do you have a specific type of organic monomer in mind? Etc.
Regards
Josef
many thanks Dears Abdelkader BOUAZIZ and Josef Chmelar , for your replies, actually I work on amino acid methacrylate , I prepared the monomer and want to synthesize polymer nanoparticle starting from the monomer, but all procedures start from the polymer instead of monomer, except the emulsion polymerization which needs surfactant, so what I need is, a procedure for polymerization of the monomer without including the drug. and surfactant-free is it possible? and regarding the drug I didn't decide which anticancer I will choose yet may be paclitaxel or doxorubicin?
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