I have been trying to find studies of adults who experienced adverse childhood events/childhood trauma that assess the link between ACEs and outcomes (bipolar disorder, PTSD/cPTSD, etc) using multiple measures to determine cause and effect.
A hypothetical example would be a study that assesses whether childhood emotional abuse/neglect (ACE) is associated with any 5-HTTLPR polymorphism (genetics), SLC6A4 hypermethylation (epigenetics), AND amygdala activity (fxn) in people with bipolar disorder (negative outcome) but not healthy controls who experienced similar severity of childhood emotional abuse/neglect
I know this is a huge lift and would require a somewhat large study but right now the story is missing a comprehensive view of the molecular and functional changes due to ACEs causes leads to negative outcomes.
Thank you in advance for any help you can give
https://www.google.com/url?sa=t&source=web&rct=j&url=https://bpded.biomedcentral.com/articles/10.1186/s40479-015-0025-x&ved=2ahUKEwivzdW5gqPwAhVJBs0KHUTXA1oQFjAAegQIBBAC&usg=AOvVaw23Pkz-YSfSDsc4JLOrzv9k
I find it quite interesting how experiences with rejection at such a young age can be associated with personality disorder development. Enjoy your research!
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