I am researching on a chemotherapeutic agent for gliomas which i intend to deliver using nanotechnology.
Is not it enough using xenograft model? For ex, U87 injected rats?
As for the injection part, brain is best but subcutaneous is also OK.
Thanx Hana
Sorry to bother you but with out MRI, how can I know that gliomas have been induced in xenograft models?
to know if the tumor was induced you can label your cell line before injection into the rats with luciferase and then you can follow tumor growth and distribution using bioluminescence technic .
example: https://bio-protocol.org/e1762
an introduction
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