Hi All,
Small and large intestine are different organs, but have similar structures and functions, here I want to ask,
1) As for intesitnal immunity development, it seems that small intestine contains more immune cells than colon, so small intestine contributes more to intesitnal immunity development?
2) Do small intestine and colon share immune cells? through what mechanism?
Thanks!
Xin
The question in not clear enough. What do you mean by immune development ? Do you mean development of immunity ?
Article Development of immune function in the intestine and its role...
https://www.cell.com/immunity/pdf/S1074-7613(17)30137-1.pdf
Article Innate immunity in the small intestine
https://www.europeanreview.org/wp/wp-content/uploads/323-333.pdf
There are different type of microbiota in different section of gut. Hence, its not suitable to deduce any of the intestine as "it contribute more". Both have its own specificity and importance.
Hi Abhijeet,
Thank you for your information.
Yes, the development of immunity, why some people research on immunity in small intestine, while other people focus on immunity in colon? are the immunity similar in small intestine and colon? or do they share the immune cells?
Xin
Hi Xin,
You can confirm it from other papers though as far as I know the mucosal lymphoid structure such as peyer's patches are more abundant in colon compared to small intestine.
This could be due to the fact that small intestine takes part in digestion and a lot of digestive enzymes are secreted in this region. Consequently the gut microbes are less abundant in this region compared to colon. As it is becoming more clear that gut microbes induce and maintain the gut mucosal immune system, it is not surprising that more organized lymphoid structure including peye'r patches are found in colon.
best,
Sudeep
Xin Wang It was a good question but your question started to loose the sense if you are arguing, why some people research on small intestine and why others research on large?
The intestines are a 7 m long structure and not constant in their structure and function. The anatomy and physiology changes throughout their length as also pointed out in previous comments. Sudeep Kumar explained it well and please read through the literature available related to the contribution of intestine in innate and acquired immunity. And if you want any specific answer, please mention about specific cells. Immune cell means nothing.
Hi Xin,
Think you'll find this paper particularly helpful. As mentioned above your questions are currently too broad/ill defined to be answered.
https://www.nature.com/articles/nri3738#abstract
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