The paper (therapy/intervention study) includes an assessment of quality and risk of bias, however does not using a GRADE approach? Would this be considered a weakness?
Including the GRADE approach in a systematic review and meta-analysis is recommended. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) helps assess the quality of evidence and strength of recommendations, enhancing the credibility and transparency of your review's findings.
Ideally, yes. see: https://www.bjanaesthesia.org.uk/article/S0007-0912(19)30643-9/fulltext#:~:text=The%20Grading%20of%20Recommendations%20Assessment,strength%20of%20clinical%20practice%20recommendations. The link takes you to a nice article on the subject in the British Journal of Anesthesia. As the article points out, though GRADE is not required by all journals, it has become the de facto standard.