Omega-3 fatty acids are related to healthy aging all over life. A moment ago, from fish, source omega-3 fatty acids DHA and EPA have been related with fetal development in AD and cognition related problems. Nevertheless, since the human body does not effectively produce few omega-3 fatty acids, while obtaining from marine sources. The brain is extremely augmented with lipids bilayers. Therefore, it is accountable to undertaken that the combination of different fatty acids within brain ha importance for brain functioning, counting neuropsychiatric and cognition development. To know the special effects form fatty acids ingestion, we need to depend on the mutual evaluation of experimental studies, observations, and interventional studies. The brain is enriched with lipid bilayers of omega-3 fatty acid constituents like DHA and EPA may have lots of effects on the brain. The potential function of omega-3 fatty acid …
Omega-3 fatty acids, eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) improve cognitive function in neurodegenerative disorders. The roles of Omega-3 fatty acids in different neurodegenerative diseases have been reported in different articles available online that you can get access. Here, are some of them:
DHA modulate neural gene expression via activation of peroxisome proliferator-activated receptor (PPAR) and stabilizing mRNA of enzymes associated with glucose and lipid metabolic pathways.
DHA acts as an endogenous ligand for retinoic acid receptors and retinoid x receptors which are associated with age-related memory deficits thereby alleviating the memory deficits and enhance neurogenesis.
DHA facilitates activation of protein kinase B (PKB) and increases levels of hippocampal BDNF which improve synaptic plasticity and promote cell survival.
DHA activates Ca2+/calmodulin-dependent protein kinase (CaMKII) which is critical for learning and memory. DHA blocks K+ channels leading to prolong potentiation for synaptic modification for long term memory and learning.
Omega-3 Fatty Acids (O3FA) are essential fatty acids that are the components of neuronal cell membranes in the brain [9–12]. Several studies have highlighted the neuroprotective roles of O3FA in neurodegenerative disorders such as HD [13] and PD [14] as well as AD and Mild Cognitive Impairment (MCI)
Actually, Neurodegenerative disorders are commonly associated with a complex pattern of pathophysiological hallmarks, including increased oxidative stress and neuroinflammation, which makes their treatment challenging. Omega-3 fatty acids (O3FA) are natural products with reported neuroprotective, anti-inflammatory, and antioxidant effects. These effects have been attributed to their incorporation into neuronal membranes or through the activation of intracellular or recently discovered cell-surface receptors (i.e., Free-Fatty Acid Receptors; FFAR)
Whereas, There is also evidence for their efficacy in psychiatric disorders such as depression [17, 18] and schizophrenia [19], which similar to neurological disorders, have a neural etiology. Despite the large body of evidence suggesting neuroprotective roles of O3FA for neurodegenerative disorders, there are currently no approved therapies for brain disease, as only Over The Counter (OTC) dietary supplements, which lack standardization and regula tion, are available.