Can I use discovery studio for simulating a compound docked with a human protein target using Glide-IFD docking?

Can I use discovery studio for simulating the complex? As glide uses OPLS2005 force field and discovery studio uses Charmm force field, will it be a logical step or not?

08 September 2013 5,171 2 View

MODELLER DOUBTS

Hi all , I installed modeller9v8 in my PC. the command page opens. but when i type as " sequence.ali", i get the following command: " 'sequence.ali' is not recognised as an internal or external...

02 March 2011 1,566 5 View

Kindly help

I am asked to look for sequence similarity and identity for a target protein which is of 120 amino acids. But I have to compare this target with a database of 1500 sequences. so i do not know...

01 February 2011 5,209 2 View

overlaps

I have a sequence of 100 amino acids. I want to see the overlapping segments in the sequence by splitting into dipeptides, tripeptides. so how to do this analysis? is there any online tool to do...

01 February 2011 7,075 2 View

suggestions please

I am asked to look for sequence similarity and identity for a target protein which is of 120 amino acids. But I have to compare this target with a database of 1500 sequences. so i do not know...

01 February 2011 9,226 2 View

FASTA

Hi, I have a sequence ( human -target)) of 600 aminoacids long. (No structure is available.). similarly i found a sequence(template) in monkey which is the same 600 amino acids long. when both...

11 December 2010 6,720 1 View

OBEJCTIVE TYPE BIOINFORMATICS BOOK- FIRST OF ITS KIND

Hi all I have published a book on 'OBJECTIVE TYPE BIOINFORMATICS" very useful for students who study for various entrance examinations. The cost of the book is Rs.200. 5% discount can be given....

11 December 2010 2,081 1 View

rosetta

Hi can anyone teach me how to work on ROSETTA 3.1? my mail : [email protected]. please send me the steps to work with rosetta

11 December 2010 5,736 1 View

Greetings to all, has any body published a scientific paper in EuroAsian Journal of BioSciences?

Greetings to all, has any body published a scientific paper in EuroAsian Journal of BioSciences and if so could you please tell me if there was any problems regarding communications with the...

05 October 2020 1,713 2 View

Do you agree with the just issued Great Barrington Declaration regarding the response to COVID-19?

The short and to-the-point text is here and I for one gladly co-signed this declaration, just as I also co-signed the balanced approach statement issued in July 2020 by 23 public health experts...

04 October 2020 8,795 11 View

The meaning of protein phosphorylation to bioscience?

Many researchers have mentioned in their researches that protein phosphorylation take a decisive position to regulate various physiological activity, from prokaryote to eukaryote. So did...

23 July 2020 7,135 3 View

Is there any cause of pellet from the culturing media?

11 June 2020 3,585 3 View

How do you reduce the static forces in canon ball packing of fruits for transportation?

Examples of how to increase the contact surface area of the bottom area? Thank you.

25 March 2020 9,187 4 View

How molecular genetics could be useful for farmers?

Molecular genetics is the branch of genetics that investigates the chemical and physical nature of genes and the mechanisms by which genes control development, growth and physiology. It is the...

03 January 2020 3,565 4 View

How molecular genetics could be useful for farmers?

Molecular genetics is the branch of genetics that investigates the chemical and physical nature of genes and the mechanisms by which genes control development, growth and physiology. It is the...

31 December 2019 3,792 4 View

Has anyone successfully stained (intracellular staining) for T-bet with the Cytofix/Cytoperm Kit from BD Biosciences??

I isolate PBMCs from human blood and try to perform intracellular staining for T-bet (i'm interested in CD19+ cells, but for now i use CD3+ as a control). I do know there are kits that are...

22 September 2019 2,889 3 View

Has anyone successfully stained (intracellular staining) for T-bet with the Cytofix/Cytoperm Kit from BD Biosciences??

I isolate PBMCs from human blood and try to perform intracellular staining for T-bet (i'm interested in CD19+ cells, but for now i use CD3+ as a control). I do know there are kits that are...

08 September 2019 5,009 3 View

So what you think that either you will choose to develop a desktop application, mobile application or the application that can run on both platforms ?

As internet usage increase web application development become a challenge, because it is mostly customer requirement that web application must be usable on both desktop computer and...

07 August 2019 1,193 3 View