If the tumor of a person who is blood group AB is not expressing A or B antigens (which are glycans) it can use galectin-9 to 'know' which cells are tumor and which cells are host. Galectin has two different ends and can bind AB-hots cells and its own glycans for signaling.
I looked for this in GBM and found zilch, should have tried mets! Doh!
Label the tumors for galectin-9 and you should see a difference.
Hello Yilong Zheng
There are conflicting results concerning an association between ABO blood group and different types of tumors. The mechanisms linking ABO blood group with cancer risk are unclear. Several hypotheses have been proposed such as modulatory role of ABO blood group antigens on several inflammatory and adhesion molecules which play an important role in tumorigenesis. Studies have also suggested structural similarity between ABO blood group antigens and several tumor antigens that could prevent the immune system from recognizing and destroying the tumor cells resulting in a greater risk of cancer development and progression. So more scientific data is required to prove the impact of blood group on overall survival.
Best.
Check if this paper is of any help:
BMJ Open Respir Res. 2019; 6(1): e000426.
doi: 10.1136/bmjresp-2019-000426
Impact of blood group on survival following critical illness: a single-centre retrospective observational study
Robert Slade,1 Raza Alikhan,2 Matt P Wise,1 Lam Germain,1 Simon Stanworth,3 and Matt Morgan📷1
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