Can the T and B cells be inhibited for a particular antigen alone? if yes, how?
will that 'inhibit' the T or B cells? suppose a particular foreign antigen is introduced into the body, how to make the body, not respond or reject it?
So, is it something like making an Ab for the immune receptors our body makes, thereby preventing its further interaction with other immune cells, and hence any immunogenic reaction?
Most responses will be quite polyclonal and therefore the anti-idiotype approach is problematic, plus generating an anti-idiotype is not itself an easy task. A more feasible approach is to use agonists to co-inhibitory receptors, as they should only inhibit T or B cells that have recently encountered antigen.
Inhibiting a specific TCR is certainly possible from a biological standpoint; there are some nice studies showing that MDSCs can inhibit antigen-specific T cell responses through nitration of specific TCRs (e.g., Mechanism of T cell tolerance induced by myeloid-derived suppressor cells, Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI., J Immunol. 2010 Mar 15;184(6):3106-16).
That being said, I don't think there's currently a good way to realistically accomplish this in a therapeutic setting, which is what it sounds like you're trying to do.
The response to a single antigen can be policlonal: Several T and B cells can recognize the same antigen. So it will quite hard to inhibit all potential responders.. One idea will be to combine the antigen with another one that is inmunodominant. Bye the way, what do you mean with reject an antigen?
Another approach will be inducing tolerance to a given antigen using one the available protocols prior to immunizing with something else containing the same antigen to which you do NOT want a response
To Hamid: What I suggested was to use an agonist, not an antagonist. I also said it will only suppress those T and B cells that are engaging antigen, or have recently engaged antigen, and therefore it would not be pan-inhibition, it would indeed be relatively antigen specific.
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