In the present study, a patient of multiple gingival recession (Miller’s class II) was treated using human Umbilical Cord Wharton’s jelly derived mesenchymal stem cells (hUCMSCs) in combination with bone regeneration poly ε-caprolactone (PCL)-graphene oxide (GO)-Cissus quadrangular(CQ)(PCL-GO-CQ) scaffold. The study was concluded with reference to clinical parameters including root coverage that was recorded at baseline, and at 2 months postoperative. The final analysis revealed a significant reduction of the gingival recession with over 70% of root coverage.