DMSO melting point is 19°C , so is it possible to remove it from the reaction mixture by cooling it to this temperature (so it becomes solid ) and then filtering it?
But with this technique all DMSO was not removed you have to extract filterate with organic solvent and added water to it ,shake properly then separate layer.Your product comes in organic layer and DMSO goes in water layer.You may be repeat process 2 times
DMSO dissolves both in organic solvent and water.Better to extract only with organic layer twice.
Little amount if DMSO more solubility in water than organic solvent.So better to give water washing to organic solvent and also advantage to use organic solvent which has density less than water
extraction is the easiest way to remove the DMSO. Water and ether extraction is generally the best, but your compound is polar ether may not be able to extract the product out. EA or DCM will highly likely extract some DMSO as well.
The freezing method you mention is more like freeze drying. You add water, cool to -78oC and apply high vacuum to lypophilise the dmso and water.
The best way to remove DMSO is to extract your compound using EA. As, EA is the best solvent which dissloved less DMSO compared to others solvents provided your compound have solubility in EA
So the standard procedure is to add your reaction mixture into water and add excess EA to extract your compound and wash your organic extract 3~4 timeswith water and finally with Brine to remove traces of DMSO.
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