Ok, it is clear for us the Gustavo Acevedo-Hernández´s answer, but Reading some publicactions many people has doubts about the three concepts. Ex: "Modules can be understood as a separated substructure of a network or pathway, e.g. the complex of fatty acid synthetase subunits may serve as an example of a module of the fatty acid biosynthesis pathway and the protein complex is a module of a protein interaction network". In Tornow S, Mewes HW. Functional modules by relating protein interaction networks and gene expression. Nucleic Acids Research. 2003;31(21):6283-6289. doi:10.1093/nar/gkg838.
Hello. This is hard question. The complexity can be seen in:
An updated evolutionary classification of CRISPR–Cas systems
Kira S. Makarova, Yuri I. Wolf, Omer S. Alkhnbashi, Fabrizio Costa, Shiraz A. Shah, Sita J. Saunders, Rodolphe Barrangou, Stan J. J. Brouns, Emmanuelle Charpentier, Daniel H. Haft, Philippe Horvath, Sylvain Moineau, Francisco J. M. Mojica, Rebecca M. Terns, Michael P. Terns, Malcolm F. White, Alexander F. Yakunin, Roger A. Garrett, John van der Oost, Rolf Backofen & Eugene V. Koonin
Nature Reviews Microbiology
13, 722–736 (2015)
A domain is an independent module and may or may not be the functional module. If function resides on that particular domain, then it becomes the functional domain. Hope this helps.
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