Innate immune response is very wide and its complete inhinition must cover all aspects of it.

Anatomic barriers

Humoral barriers

•Complement system

•Interleukins

Cellular barriers

•Neutrophils

•Macrophages

•Dendritic cells

•Natural Killer (NK) cells

So you must think more specific about this topic. it means inhibition of particular parts of innate immune system must be addressed.

Innate immune response is very wide and its complete inhinition must cover all aspects of it.

Anatomic barriers

Humoral barriers

•Complement system

•Interleukins

Cellular barriers

•Neutrophils

•Macrophages

•Dendritic cells

•Natural Killer (NK) cells

So you must think more specific about this topic. it means inhibition of particular parts of innate immune system must be addressed.

Yes it is very wide subject. For complement system, its activation is inhibited by C1-inhibitor, CFH and CFI all depends on the pathway cascade.

How about neutrophil??

There are some techniques to inhibit those different parts, but I don't know of any that can globally inhibit ALL of the innate/nonspecific response. WIth regard to neutrophils, Journal of Leukocyte Biology. 2008;83:64-70 has a good review. Hope that helps!

I do not wish to be facetious.

However, if you want to reduce all aspects of the innate immune system, I think that the best way would be to systematically reduce the body temperature of the organism and see which of the aspects such as Anatomic barriers Humoral barriers •Complement system •Interleukins Cellular barriers •Neutrophils •Macrophages •Dendritic cells •Natural Killer (NK) cells are impaired first!

Well...I'm sorry I didn't make myself clear, actually I'm wondering what physiological phenomenons can regulate innate immunity, like Treg can suppress adaptive immunity by interfering antigen presenting, but is there any known mechanisms designed to inhibit innate immunity?

The peptides and lipids of the bacteria can influence the processes of regulation of innate immunity.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242998/?tool=pubmed

Regards and Happy New Year

QFB Pablo Fregoso

http://www.jbc.org/content/early/2011/12/13/jbc.M111.320341.long

It depends on what you want. You can inhibit cytokines, or block receptors by monoclonal antibodies.. mostly these 2 are commonly used in treating autoimmune disorders..

Stress is the major driver of decreased innate immunity. And, cortisol is the primary mediator. Cortisol tends to specifically inhibit M1-type macrophages, so that the immune system becomes M2/Th2 dominant, characterized by elevated allergic type responses

Monoclonal Ab are a good bet. There are many in vivo blocking Ab available.

pls check this article. hope it helps.

Nature 460, 520-524 (23 July 2009) | doi:10.1038/nature08138; Received 25 March 2009; Accepted 8 May 2009; Published online 28 June 2009;

Regulation of the innate immune response by threonine-phosphatase of Eyes absent

Yasutaka Okabe1,2,3,4, Teruyuki Sano1,4 & Shigekazu Nagata1,2

You could use monoclonal antibodies to Gr-1 or F4/80 for depleting neutrophil or macrophages populations resp by injecting i.v .

I think the best and effective method Macrophage Depletion by Clodronate.....

cholinergic anti-inflammatory pathway through vagus nerve, inhibit Th1, M1 towards Th2 or M2 type reaction.